Comparing the efficacy of lycopene & lycopene with hyaluronidase in management of oral sub mucous fibrosis-A clinical study

---

Original Article

Author Details : Md. Asdullah*, Juhi Gupta, Shahla Khan, Prommod Yadav, Nasir A Salati, Prathuman Verma

Volume : 10, Issue : 2, Year : 2022

Article Page : 58-61

https://doi.org/10.18231/j.jds.2022.016

Suggest article by email

Get Permission

---

Abstract

Introduction: Oral submucous fibrosis (OSMF) is a scarring disease of the oral cavity that develops over time. Lycopene is a potent antioxidant found in tomatoes that has the best singlet oxygen quenching capability and a strong capacity to quench other free radicals in vitro of all the dietary carotenoids. A protein called hyaluronidase, which is found in mammalian sperm and testes, hydrolyzes hyaluronic acid to alter the permeability of connective tissue.
Objective: To determine the effectiveness of lycopene and lycopenehyaluronidase in treating OSMF, as well as a comparison of their effectiveness.
Materials and Methods : 45 people with OSMF were enrolled in the study and divided into three groups. Patients in Group A received two evenly divided doses of Lycored 16 mg twice daily for three months. Patients in Group B received LycoRed and a 1500 IU intralesional injection of hyaluronidase twice a week for three months. Patients in Group C received placebo pills. The patients were evaluated at the end of three months. We observed the opening of the mouth, visual examination, palpatory findings, and burning sensation.
Results: For lycopene and lycopene–hyaluronidase combination, there was a statistically significant difference in mouth opening and burning sensation compared to placebo.

Keywords: Lycopene, Hyaluronidase, Oral Submucous Fibrosis

How to cite : Asdullah M, Gupta J, Khan S, Yadav P, Salati N A, Verma P, Comparing the efficacy of lycopene & lycopene with hyaluronidase in management of oral sub mucous fibrosis-A clinical study. J Dent Spec 2022;10(2):58-61

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.