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- DOI 10.18231/j.jds.12383.1891550475
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Oral squamous cell carcinoma with extensive mandibular involvement: Unveiling the role of bone invasion patterns, tumor biology and molecular prognosticators with c-Myc and PanCK expression
Background: Craniofacial and gnathic skeleton is primarily responsible for housing a myriad of benign and malignant neoplasms. Tumor biology and heterogeneity may have contributed to the lack of significant improvements in the clinical outcome of the disease despite advances in diagnosis and therapy. Although there is constant evolution of the TNM staging for oral squamous cell carcinoma, it does not encompass the complexities of the variation in bone invasion. Diving into the depths of the tumor microenvironment could significantly affect the prognosis and the treatment modality.
Case Report: A case of a 43-year-old male patient complained pain and swelling with pus discharge in left lower front and back tooth region for 6 months. Initial treatment was extraction of mandibular posterior teeth and diagnosing a hyperkeratotic patch in a private set up. On aggravation of symptoms, radiological investigation revealed extensive osteolytic, ill-defined radiolucent lesionextending from mesial of #43 region, crossing midline till the left molar and ramus region. Incisional biopsy demonstrated moderately differentiated OSCC. Histology of the resected specimen reconfirmed the squamous cell origin bone destruction. Assessment of the cervical lymph nodes revealed level IIa positive for tumor cell infiltration.
Discussion & Conclusion: Thorough assessment of the tumor microenvironment with a comprehensive set of immunomarkers and genomic analysis is vital to predict the biological behaviour of oral malignancies. Subsequently, there could be an alteration within the treatment modalities including surgical margins along with potential for targeted therapies.
References
- Ramasubramanian S, Pandiar D , Krishnan RP, Ramalingam K, Molina RB. Correlation of Bony Invasion With Nodal Metastasis, Pattern of Invasion and Survival in Oral Squamous Cell Carcinoma: A Retrospective Analysis of 122 Primary Cases From Oral Cancer Centre of South India. Cureus. 2023;15(8):e42887
- Rabelo GD , Camillo CC , Kowalski LP , Muzy NP , Roux JP , Chavassieux P, et al. Evaluation of cortical mandibular bone in patients with oral squamous cell carcinoma. Clin Oral Investig. 2018;22(2):783–90.
- Vanini JV, Koyama LKS, de Matos LL, Junior JMF, Claudio Cernea CR, Nagano CP. Epithelial-mesenchymal transition related to bone invasion in oral squamous cell carcinoma. J Bone Oncol. 2022:33:100418.
- Vaassen LA, Speel EJ, Kessler PA. Bone invasion by oral squamous cell carcinoma: molecular alterations leading to osteoclastogenesis– a review of literature. J Cranio-Maxillofacial Surg. 2017;45(9):1464–71.
- Lubek JE, Magliocca KR. Evaluation of the Bone Margin in Oral Squamous Cell Carcinoma. Oral Maxillofac Surg Clin North Am. 2017:29(3);281–92.
- Dik A, Ipenburg NA, Kessler PA, van Es RJJ, Willems SM. The value of histological grading of biopsy and resection specimens in early stage oral squamous cell carcinomas. J Cranio-Maxillofac Surg. 2018:46(6):1001–6.
- Pandey M, Rao LP, Das SR, Mathews A, Chacko EM, Naik BR. Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region. World J Surg Oncol. 2007;5:12.
- Patel K, Bhat FA, Patil S, Routray S, Mohanty N, Nair B. Whole- Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits. Front Oncol. 2021:11:660696
- Pallavi N, Nalabolu GRK, Hiremath SKS. Bcl-2 and c-Myc expression in oral dysplasia and oral squamous cell carcinoma: An immunohistochemical study to assess tumor progression. J Oral Maxillofac Pathol. 2018;22(3):325–31.
- Quan J, HouY, Long W, Ye S, Wang Z. Characterization of different osteoclast phenotypes in the progression of bone invasion by oral squamous cell carcinoma. Oncol Rep. 2018;39(3):1043–51.
How to Cite This Article
Vancouver
Jain A, Chatterjee S, Shetty DC, Gulati N. Oral squamous cell carcinoma with extensive mandibular involvement: Unveiling the role of bone invasion patterns, tumor biology and molecular prognosticators with c-Myc and PanCK expression [Internet]. J Dent Spec. 2025 [cited 2025 Oct 01];13(2):299-302. Available from: https://doi.org/10.18231/j.jds.12383.1891550475
APA
Jain, A., Chatterjee, S., Shetty, D. C., Gulati, N. (2025). Oral squamous cell carcinoma with extensive mandibular involvement: Unveiling the role of bone invasion patterns, tumor biology and molecular prognosticators with c-Myc and PanCK expression. J Dent Spec, 13(2), 299-302. https://doi.org/10.18231/j.jds.12383.1891550475
MLA
Jain, Anshi, Chatterjee, Shreya, Shetty, Devi Charan, Gulati, Nikita. "Oral squamous cell carcinoma with extensive mandibular involvement: Unveiling the role of bone invasion patterns, tumor biology and molecular prognosticators with c-Myc and PanCK expression." J Dent Spec, vol. 13, no. 2, 2025, pp. 299-302. https://doi.org/10.18231/j.jds.12383.1891550475
Chicago
Jain, A., Chatterjee, S., Shetty, D. C., Gulati, N.. "Oral squamous cell carcinoma with extensive mandibular involvement: Unveiling the role of bone invasion patterns, tumor biology and molecular prognosticators with c-Myc and PanCK expression." J Dent Spec 13, no. 2 (2025): 299-302. https://doi.org/10.18231/j.jds.12383.1891550475