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- DOI 10.18231/j.jds.9679.1405469647
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Clinical evaluation of topical application of anti-oxidant coenzyme Q10 on periodontal status in diabetic patients- Randomized control trial
Introduction: Gingivitis and periodontitis are linked to the excessive production of oxygen species and some free radicals), which can contribute to tissue destruction. Coenzyme Q10 (CoQ10), a powerful natural antioxidant, exists in two forms: the oxidized form and the reduced form. It functions as a ROS scavenger and may help reduce periodontal inflammation.
Aim: To assess and compare the therapeutic efficacy of topical Coenzyme Q10 application versus conventional scaling and root planing alone in enhancing periodontal health, as measured by changes in the Gingival Index and the Community Periodontal Index of Treatment Needs (CPITN) at baseline, 3 weeks, and 6 weeks.
Materials and Methods: A total of 32 diabetic patients divided into 2 groups. One group is exposed to topical application (extrasulcular) Coenzyme Q10 & SRP and 2nd group is exposed to SRP only. Clinical parameters, including the Gingival Index and CPITN index, were evaluated at baseline, at the end of the 3rd week, and at the 6th week.
Results: Intra-group comparison was done both the indices gingival index (GI), Community periodontal index of treatment needs(CPITN) showed significant reduction in the scores but the results where statistically non-significant in all 2 treatment groups.
Conclusion: Antioxidant is effective in reducing the gingival inflammation among diabetic patients.
References
- Hans M, Prakash S, Gupta S. Clinical evaluation of topical application of perio-Q gel (Coenzyme Q(10)) in chronic periodontitis patients. J Indian Soc Periodontol. 2012;16(2):193–9.
- Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. 2000;11(2):109–13.
- Manthena S, Rao MV, Penubolu LP, Putcha M, Harsha AV. Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health. J Clin Diagn Res. 2015;9(8):ZC26–8.
- Raut CP, Sethi KS. Comparative evaluation of co-enzyme Q10 and Melaleuca alternifolia as antioxidant gels in treatment of chronic periodontitis: A clinical study. Contemp Clin Dent. 2016;7(3):377–
- Matthews-Brzozowska T, Kurhañska -Flisykowska A, Wyganowska-OEwi¹tkowska M, Stopa J. Healing of periodontal Chintale et al. / Journal of Dental Specialities 2025;13(2):267-274 273 tissue assisted by Coenzyme Q10 with Vitamin E – clinical and laboratory evaluation. Pharmacol Rep. 2007;59(Suppl 1):257–60.
- Ghasemi S, Torab Z, Shirmohammadi A, Babaloo A, Johari R, Farhadi F, et al. Evaluation of the effect of coenzyme Q10 supplementation along with scaling and root planing (SRP) on periodontal and gingival indices in controlled diabetic patients. J Adv Periodontol Implant Dent. 2022;14(1):32–7.
- Altman LC, Baker C, Fleckman P, Luchtel D, Oda D. Neutrophil- mediated damage to human gingival epithelial cells. J Periodontal Res. 1992;27(1):70–9.
- Waddington RJ, Moseley R, Embery G. Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis. 2000;6(3):138–51.
- Canakçi CF, Ciçek Y, Canakçi V. Reactive oxygen species and human inflammatory periodontal diseases. Biochemistry. 2005;70(6):619–28.
- Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol. 1997;82:291- 95. [7] Halliwell B, Gutteridge JM. Free radicals in biology and medicine, 2nd ed. Oxford: Clarendon Press, 1989.
- Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med. 1999;10(4):458–76.
- Littarru GP, Nakamura R, Ho L, Folkers K, Kuzell WC. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proc Natl Acad Sci U S A. 1971;68(10):2332–5.
- Hansen IL, Iwamoto Y, Kishi T, Folkers K, Thompson LE. Gingival and leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease. Res Commun Chem Pathol Pharmacol. 1976;14(4):729–38.
- Loesche WJ, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev. 2001;14(4):727–52.
- Lamster IB, Novak MJ. Host mediators in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. Crit Rev Oral Biol Med. 1992;3(1-2):31–60.
- Nakamura R, Littarru GP, Folkers K, Wilkinson EG. Study of CoQ1o-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of Coenzyme Q10. Proc Natl Acad Sci USA. 1974;71(4):1456–60.
- Wilkinson EG. Bioenergetics in clinical medicine.II. Adjunctive treatment with coenzyme Q in periodontal treatment. Res Commun Chemic Path Pharmac. 1975;12(1);111–23.
- Shizukuishi S, Hanioka T, Tsunemitsu A, Fukunaga Y, Kishi T, Sato N. Clinical effect of Coenzyme 010 on periodontal disease; evaluation of oxygen utilisation in gingiva by tissue reflectance spectrophotometry. In: Biomedical and clinical aspects of Coenzyme Q. Amsterdam: Elsevier; 1986;5:359-68
- McRee JT, Hanioka T, Shizukuishi S, Folkers K. Therapy with Coenzyme Q10 for patients with periodontal disease. 1. Effect of Coenzyme Q10 on subgingival micro-organisms. J Dent Health. 1993;43:659–66.
- Thomas AE, Varma B, Kurup S, Jose R, Chandy ML, Kumar SP, et al. Evaluation of Efficacy of 1% Cur‐ cuminoids as Local Application in Management of Oral Lichen Planus‐ Interventional Study. J Clin Diagn Res. 2017;11(4):89–93.
How to Cite This Article
Vancouver
Chintale S, Vishwakarma P, Zadode AS, Ghune D, Chhabile S, Wankhede S. Clinical evaluation of topical application of anti-oxidant coenzyme Q10 on periodontal status in diabetic patients- Randomized control trial [Internet]. J Dent Spec. 2025 [cited 2025 Oct 01];13(2):267-274. Available from: https://doi.org/10.18231/j.jds.9679.1405469647
APA
Chintale, S., Vishwakarma, P., Zadode, A. S., Ghune, D., Chhabile, S., Wankhede, S. (2025). Clinical evaluation of topical application of anti-oxidant coenzyme Q10 on periodontal status in diabetic patients- Randomized control trial. J Dent Spec, 13(2), 267-274. https://doi.org/10.18231/j.jds.9679.1405469647
MLA
Chintale, Snehal, Vishwakarma, Prashanth, Zadode, Ashwini S, Ghune, Divya, Chhabile, Sujata, Wankhede, Saloni. "Clinical evaluation of topical application of anti-oxidant coenzyme Q10 on periodontal status in diabetic patients- Randomized control trial." J Dent Spec, vol. 13, no. 2, 2025, pp. 267-274. https://doi.org/10.18231/j.jds.9679.1405469647
Chicago
Chintale, S., Vishwakarma, P., Zadode, A. S., Ghune, D., Chhabile, S., Wankhede, S.. "Clinical evaluation of topical application of anti-oxidant coenzyme Q10 on periodontal status in diabetic patients- Randomized control trial." J Dent Spec 13, no. 2 (2025): 267-274. https://doi.org/10.18231/j.jds.9679.1405469647