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- DOI 10.18231/j.jds.11605.1768837041
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CrossMark
Salivary albumin as a potential biomarker for dental caries in adult population in Haryana: Evidence from an in vivo study
- Author Details:
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Deepti Nandana
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Ashtha Arya
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Gourav Thapak
Ashtha Arya
Introduction: Dental caries remains a prevalent oral health concern, with saliva playing a crucial role in its prevention and progression. Among salivary components, albumin has gained attention as a potential biomarker, prompting this study to explore its correlation with the severity of dental caries.
Aim and Objective: The study investigated the correlation between salivary albumin levels and dental caries in the adult population of Haryana based on Decayed, Missing, and Filled Teeth (DMFT) scores.
Materials and Methods: The study was conducted on sixty adult participants who were divided into 4 groups based on their Decayed, Missing and Filled Teeth scores: Group 1 (DMFT 0, caries-free), Group 2 (DMFT 1-5), Group 3 (DMFT 6-10), and Group 4 (DMFT >10). Standardized procedures were used to obtain unstimulated saliva samples from each participant. Salivary albumin levels were measured using the Agappe albumin kit and the bromocresol green technique. One-way ANOVA and Tukey's post-hoc test were used to statistically analyze the collected data, with a significance threshold of p < 0.05.
Results: Salivary albumin levels and DMFT scores were found to be significantly inversely correlated by statistical analysis (p = 0.001). The mean salivary albumin levels were highest in Group 1 (0.34 ± 0.08 mg/mL) and progressively decreased across Group 2 (0.33 ± 0.08 mg/mL), Group 3 (0.20 ± 0.11 mg/mL), and Group 4 (0.12 ± 0.04 mg/mL). Post-hoc analysis confirmed significant differences between caries-free individuals and those with high DMFT scores.
Conclusion: The findings of this study suggest that lower salivary albumin levels are associated with increased susceptibility to dental caries.
References
- Hegde MN, Attavar SH, Shetty N, Hegde ND, Hegde NN. Saliva as a biomarkers for dental caries: A systematic review J Conserv Dent. 2019;22(1):2–6.
- Hegde MN, Sajnani AR. Salivary Proteins-A Barrier on Enamel Demineralization: An in vitro Study. Int J Clin Pediatr Dent. 2017;10(1):10–3.
- Spatafora G, Li Y, He X, Cowan A, Tanner ACR. The Evolving Microbiome of Dental Caries. Microorganisms. 2024;12(1):121.
- Hegde MN, Bhat R, Punja A, Shetty C. Correlation Between Dental Caries and Salivary Albumin in Adult Indian Population–An In Vivo Study. J Adv Med Med Res. 2014;4(25):4238–44.
- Khandelwal A., Palanivelu A. Correlation Between Dental Caries And Salivary Albumin In Adult Population In Chennai: An In Vivo Study. Braz Dent. Sci. 2019;22(2):228–33.
- Martins C, Buczynski A, Maia LC, Siqueira WL, Castro GF. Salivary proteins as a biomarker for dental caries: A systematic review. J Dent. 2013;41(1):2–8.
- Vaish S, Gautam K, Agrawal D, Ali AR, Choudhary A, Goyal A. Comparison between Serum and Salivary Albumin and Calcium Levels in Adolescent Age-group with Dental Caries. Int J Clin Pediatr Dent. 2024;17(3):328–33.
- Yang TY, Zhou WJ, Du Y, Wu ST, Yuan WW, Yu Y, et al. Role of saliva proteinase 3 in dental caries. Int J Oral Sci. 2015;7:174–8.
- Dawes C. Salivary flow patterns and the health of hard and soft oral tissues. J Am Dent Assoc. 2008;139(2):18S–24S.
- Edgar WM. Saliva: its secretion, composition, and functions. Br Dent J. 1992;172(8):305–12.
- Lenander-Lumikari M, Loimaranta V. Saliva and dental caries. Adv Dent Res. 2000;14(1):40–7. 266 Nandana et al. / Journal of Dental Specialities 2025;13(2):262-266
- Greabu M, Didilescu A, Puiu L, Miricescu D, Totan A. Salivary antioxidant biomarkers in non-ferrous metals mine workers – a pilot study. J Oral Pathol Med. 2012;41(6):490–3.
- Alamoudi, A.; Alamoudi, R.; Gazzaz, Y.; Alqahtani, A.M. Role of Salivary Biomarkers in Diagnosis and Detection of Dental Caries: A Systematic Review. Diagnostics. 2022;12:3080. doi:
- 3390/diagnostics12123080.
- Ahmad P, Hussain A, Carrasco-Labra A, Siqueira WL. Salivary Proteins as Dental Caries Biomarkers: A Systematic Review. Caries Res. 2022;56(4):385–98
- Khan ZM, Waheed H, Khurshid Z, Zafar MS, Moin SF, Alam MK. Differentially Expressed Salivary Proteins in Dental Caries Patients. Biomed Res Int. 2021;2021:5517521.
- Shore RC, Kirkham J, Brookes SJ, Wood SR, Robinson C. The presence of albumin in demineralized enamel. Caries Res. 2000;34(2):106–11.
- Perez VA, Mangum JE and Hubbard MJ. Pathogenesis of Molar Hypomineralisation: Aged Albumin Demarcates Chalky Regions of Hypomineralised Enamel. Front Physiol. 2020;11:579015
- Mahmood MK, Kurda HA, Qadir BH, Tassery H, Lan R, Tardivo D, et al. Implication of serum and salivary albumin tests in the recent oral health related epidemiological studies: A narrative review. Saudi Dent J. 2024;36(5):698–707
- Raja M, Nazzal H, Cyprian FS, Matoug-Elwerfelli M, Duggal M. Association of salivary proteins with dental caries in children with mixed dentition: a systematic review. Eur Arch Paediatr Dent. 2025;26(4):617–31.
- Mandel ID. The functions of saliva. J Dent Res. 1987;66(Spec Iss):623–7.