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- DOI 10.18231/j.jds.41431.1759130456
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Comparative evaluation of the efficacy of platelet-rich plasma and dexamethasone injections in myofascial pain trigger points in the masseter muscle
Background: Myofascial pain syndrome (MPS) is characterized by muscle pain and tenderness, often associated with myofascial trigger points (MTrPs). These MTrps can cause referred pain and muscle dysfunction, such as in the masseter. Platelet-rich plasma (PRP) therapy has emerged as a treatment for myofascial pain due to its regenerative properties, while corticosteroids like dexamethasone are commonly used for their anti-inflammatory effects. This study aims to compare the efficacy of PRP and dexamethasone injections in treating MTrPs in the masseter muscle.
Materials and Methods: This study involved 30 participants (age 18-40) with active MTrPs in the masseter muscle. Participants were randomly assigned to two groups to receive either dexamethasone (Group 1, Dexamethasone =15) or platelet-rich plasma (Group 2, PRP 15). Pain levels were measured using the Visual Analog Scale (VAS), and functional outcomes were assessed via Maximum Interincisal Opening (MIO) and Pain Perception Index (PPI) at baseline, Day 0, Day 5, Day 15, and one month
Results: Both treatments significantly reduced pain and improved functional outcomes (MIO and PPI) over time. No significant differences were found between the PRP and dexamethasone groups in pain reduction or functional improvements (p > 0.05).
Conclusion: PRP and dexamethasone are equally effective in managing pain and improving function in MPS. Larger studies with longer follow-ups are needed to confirm these findings.
References
- Morad A, Abdellatif E M, Elmohandes W A. Evaluation of the role of platelet-rich plasma injection in trigger points for treatment of myofascial pain. Al-Azhar J Dent Sci. 2018;21(4):347–55.
- Abdel Aziz OM, Abdelmoneim HS. Myofascial pain treatment: local anesthesia injection versus corticosteroids. (Randomized controlled clinical trial). Egyp Dent J. 2019;65(4):3349–55.
- Dakrory U. Comparative study between usage of Platelet-Rich Plasma and Botulinum toxin a injection in management of Myofascial pain dysfunction. (A Randomized Clinical Trial). Egyp Dent J. 2022;68(1):121–33.
- Khalil SI. Effect of Perineural Dextrose Injection on Myofascial Pain Syndrome. AlAnbar Med J. 2022;18(2):61–5.
- Urits I, Charipova K, Gress K, Schaaf AL, Gupta S, Kiernan HC, Choi PE, et al. Treatment and management of myofascial pain syndrome. Best Pract Res Clin Anaesthesiol. 2020;34(3):427–48.
- Galasso A, Urits I, An D, Nguyen D, Borchardt M, Yazdi C, et al. A comprehensive review of the treatment and management of myofascial pain syndrome. Curr Pain Headache Rep. 2020 Jun 27;24(8):43.
- Nitecka-Buchta A, Walczynska-Dragon K, Kempa WM, Baron S. Platelet-rich plasma intramuscular injections—antinociceptive therapy in myofascial pain within masseter muscles in temporomandibular disorders patients: A pilot study. Front Neurol. 2019;10:250.
- Peter I, Wu K, Diaz R, Borg-Stein J. Platelet-rich plasma. Phys Med Rehabil Clin N Am. 2016;27(4):825-53.
- Johnson DB, Lopez MJ, Kelley B. Dexamethasone. InStatPearls [Internet] StatPearls Publishing, 2022. 246 Saba et al. / Journal of Dental Specialities 2025;13(2):240-246
- Liu J, Liu Z, Tang Y, Munoz A, Zhang Y, Li X. Treatment with platelet-rich plasma attenuates proprioceptor abnormalities in a rat model of postpartum stress urinary incontinence. Int Urogynecol J. 2022;33(8):2159–67.
- Sell SA, Ericksen JJ, Reis TW, Droste LR, Bhuiyan MB, Gater DR. A case report on the use of sustained release platelet-rich plasma for the treatment of chronic pressure ulcers. J Spinal Cord Med. 2011;34(1):122–7
- Raeissadat SA, Sedighipour L, Rayegani SM, Bahrami MH, Bayat M, Rahimi R. Effect of platelet-rich plasma (PRP) versus autologous whole blood on pain and function improvement in tennis elbow: a randomized clinical trial. Pain Res Treat. 2014:191525.
- Aufiero D, Vincent H, Sampson S, Bodor M. Regenerative injection treatment in the spine: Review and case series with platelet-rich plasma. J Stem Cells Res Rev Rep. 2015;2(1):1019.
- El Mallah RM, Elattar EA, Zidan HF. Platelet-rich plasma versus dry needling of myofascial meridian trigger points in the treatment of plantar fasciitis. Egyp Rheumatol Rehabil. 2017;44:58–68.
- Yilmaz O, Sivrikaya EC, Taskesen F, Pirpir C, Ciftci S. Comparison of the efficacy of botulinum toxin, local anesthesia, and platelet-rich plasma injections in patients with myofascial trigger points in the masseter muscle. J Oral Maxillofac Surg. 2021;79(1):88.e1–9.
- Abaas RA, Sabry HA, Kamel HM, Awadallah NM. Clinical impact of magnesium sulfate injection versus local anesthetic injection on pain management in patients with myofascial pain dysfunction syndrome: a randomized clinical study. Egyp Dent J. 2025;71(1):145–53.
- Aglan AM, Eldibany MM, Noureldin M, Abdel-Naby HM. Comparative study between botulinum toxin a and platelet-rich plasma in the treatment of myofascial pain within masseter muscle (a randomized clinical trial). Alexandria Dent J. 2024;49(2):91–9.
- Anwar N, Wei X, Jie Y, Hongbo Z, Jin H, Zhu Z. Current advances in the treatment of myofascial pain syndrome with trigger point injections: A review. Medicine. 2024;103(40):e39885.
- Saglam R, Delilbasi C, Ozel GS, Subasi ID. Evaluation of the effects of occlusal splint and masseter muscle injection in patients with myofascial pain: a randomised controlled trial. J Oral Facial Pain Headache. 2024;38(3):64–76.
- Kostopoulos D, Rizopoulos K. The manual of trigger point and myofascial therapy. Routledge. 2024.
- Bentsianov B, Francis A, Blitzer A. Botulinum toxin treatment of temporomandibular disorders, masseteric hypertrophy, and cosmetic masseter reduction. Operative Tech Otolaryngology-Head Neck Surg. 2004;15(2):110–3.
- Anitua E, Prado R, Sánchez M, Orive G. Platelet-rich plasma: preparation and formulation. Operative Techn Orthop. 2012;22(1):25–32.
- Okeson J. Management of temporomandibular disorders and occlusion.7th ed Mosby Elsevier (USA), 2013:273–75.
- Reurink G, Goudswaard G, Moen M, Weir A, Verhaar J, Bierma- Zeinstra S, et al . Platelet-rich plasma injections in acute muscle injury. N Engl J Med. 2014,370(26):2546–7.
- Refahee SM, Mahrous AI, Shabaan AA. Clinical efficacy of magnesium sulfate injection in the treatment of masseter muscle trigger points: A randomized clinical study. BMC Oral Health [Internet]. 2022;22(1):408.
- Lee C, Song YK, Jeong HM, Park SN. The effects of magnesium sulfate infiltration on perioperative opioid consumption and opioid- induced hyperalgesia in patients undergoing robot-assisted laparoscopic prostatectomy with remifentanil-based anesthesia. Korean J Anesthesiol [Internet]. 2011;61(3):244–50.
- Korkmaz N, Örücü Atar M, Uyar Köylü S, Aslan SG, Tezen Ö, Kesikburun S. Comparison of the efficacy of oxygen-ozone and lidocaine injections in the treatment of myofascial pain syndrome: A randomized clinical trial. Turk J Phys Med Rehabil [Internet]. 2023;69(3):294–302.
- Hasuo H, Matsuoka H, Matsuda Y, Fukunaga M. The Immediate Effect of Trigger Point Injection With Local Anesthetic Affects the Subsequent Course of Pain in Myofascial Pain Syndrome in Patients With Incurable Cancer by Setting Expectations as a Mediator. Front Psychiatry [Internet]. 2021;12:592776.
- Peng YN, Sung FC, Huang ML, Lin CL, Kao CH. The use of intravenous magnesium sulfate on postoperative analgesia in orthopedic surgery: A systematic review of randomized controlled trials. Medicine (Baltimore) [Internet]. 2018;97(50):e13583.
- Yadav U, Ahmed J, Ongole R, Shenoy N, Sujir N, Nata Rajan S. Influence of Psychosocial Factors and Parafunctional Habits in Temporomandibular Disorders: A Cross-Sectional Study. Perm J [Internet]. 2020;24:144.
- Hohmann E, Tetsworth K, Glatt V. Platelet-rich plasma versus corticosteroids for the treatment of plantar fasciitis: A systematic review and meta-analysis. Am J Sports Med. 2021;49(5):1381–93.
How to Cite This Article
Vancouver
Saba Q, Rathore A, Yadav A, Pradhan S, Waikhom S, Uma A. Comparative evaluation of the efficacy of platelet-rich plasma and dexamethasone injections in myofascial pain trigger points in the masseter muscle [Internet]. J Dent Spec. 2025 [cited 2025 Oct 01];13(2):240-246. Available from: https://doi.org/10.18231/j.jds.41431.1759130456
APA
Saba, Q., Rathore, A., Yadav, A., Pradhan, S., Waikhom, S., Uma, A. (2025). Comparative evaluation of the efficacy of platelet-rich plasma and dexamethasone injections in myofascial pain trigger points in the masseter muscle. J Dent Spec, 13(2), 240-246. https://doi.org/10.18231/j.jds.41431.1759130456
MLA
Saba, Qazi, Rathore, Akshay, Yadav, Anuradha, Pradhan, Saplin, Waikhom, Sylvia, Uma, Achom. "Comparative evaluation of the efficacy of platelet-rich plasma and dexamethasone injections in myofascial pain trigger points in the masseter muscle." J Dent Spec, vol. 13, no. 2, 2025, pp. 240-246. https://doi.org/10.18231/j.jds.41431.1759130456
Chicago
Saba, Q., Rathore, A., Yadav, A., Pradhan, S., Waikhom, S., Uma, A.. "Comparative evaluation of the efficacy of platelet-rich plasma and dexamethasone injections in myofascial pain trigger points in the masseter muscle." J Dent Spec 13, no. 2 (2025): 240-246. https://doi.org/10.18231/j.jds.41431.1759130456