Clinical Evaluation of topical application Of Anti-Oxidant Coenzyme Q10 On Periodontal Status in Diabetic Patients- Randomized Control Trial

Authors: Dr Saloni Dnyaneshwar Wankhede, Dr Sujata Rajesh Chhabile, Dr Snehal Bhagwan Chintale, Dr Prashanth Vishwakarma, Dr Ashwini S Zadode, Dr Divya Devendra Ghune

DOI: 10.18231/j.jds.9679.1405469647

Keywords: Antioxidants, periodontitis, coenzyme Q10, gingivitis, topical application

Abstract: INTRODUCTION: :Gingivitis & Periodontities caused by overproduction of free radicals and reactive oxygen species (ROS)that may increase tissue breakdown. Coenzyme Q10 (CoQ10) serves as potent endogenous antioxidant that exists in an oxidized form (ubiquinone or CoQ) and a reduced form (ubiquinol or CoQH2) act as a scavenger to ROS and may be suppress the periodontal inflammation. AIM- To evaluate and compare the effectiveness of topical application Coenzyme Q10 and scaling and root planing on Gingival Index, Community periodontal index of treatment needs (CPITN) Index at the first visit, 3 weeks, and 6 weeks. MATERIAL & METHODOLOGY- A total of 32 diabetic patients divided into 2 groups. One group is exposed to topical application (extrasulcular) Coenzyme Q10 & SRP and 2nd group is exposed to SRP only. Clinical parameters such as Gingival Index, Community periodontal index of treatment needs(CPITN) Index were assessed at baseline, end of 3rd week, and 6th week respectively. RESULTS- Intra-group comparison was done both the indices gingival index (GI), Community periodontal index of treatment needs(CPITN) showed significant reduction in the scores but the results where statistically non significant in all 2 treatment groups. CONCLUSION- Antioxidant is effective in reducing the gingival inflammation among diabetic patients